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武汉赛培试剂盒文章：人IL-6，IL-1α，CRP
发布时间：2024-04-01 15:25:04
乳腺导管探查术对乳汁淤积患者泌乳症状、炎性介质的影响
龙安莉，刘勋娇，周国栋，王新绸 ［基金项目］ 广西壮族自治区卫生健康委员会自筹经费科研课题( Z20190685) ［作者单位］ 541001 广西壮族自治区 桂林，桂林市妇幼保健院乳腺科 ［作者简介］ 龙安莉，本科，副主任医师。主要从事乳腺外科方向研究 ［通讯作者］ 刘勋娇，E-mail: 584493407@ qq． com ［摘要］ 目的 探讨乳腺导管探查术对乳汁淤积患者泌乳症状、炎性介质的影响。方法 选取 2020 年 8 月— 2021 年 8 月收治的乳汁淤积 300 例，根据治疗方法的不同分为观察组和对照组各 150 例，对照组采取传统物理疗法， 观察组采取乳腺导管探查术。统计比较 2 组治疗效果、康复相关指标( 泌乳开始时间、乳房肿块消失时间、乳汁排出 量、母乳喂养情况) 、患者满意度及不良事件、复发情况，治疗前后泌乳症状评分及炎性介质［血清白细胞介素-6 ( IL-6) 、白细胞介素-1α( IL-1α) 、C 反应蛋白( CＲP) ］。结果 观察组治疗总有效率、患者总满意度高于对照组，泌乳 开始时间、乳房肿块消失时间短于对照组，乳汁排出量多于对照组，母乳喂养情况优于对照组( P ＜ 0. 05，P ＜ 0. 01) 。 治疗后 2 组乳汁淤积、乳汁质量、泌乳量、乳房充盈度、乳房疼痛评分均高于治疗前，且观察组高于对照组( P ＜ 0. 05， P ＜ 0. 01) 。治疗后 2 组血清 IL-1α、IL-6、CＲP 均低于治疗前，且观察组低于对照组( P ＜ 0. 05，P ＜ 0. 01) 。2 组不良事 件发生率及复发率比较差异无统计学意义( P ＞ 0. 05) 。结论 乳腺导管探查术治疗乳汁淤积效果确切，有助于缓解 泌乳症状，提高母乳喂养率及患者满意度，下调炎性介质，且具有一定安全性。 ［关键词］ 乳汁淤积; 哺乳期; 乳腺导管探查术; 泌乳症状; 白细胞介素-6; C 反应蛋白 ［中国图书资料分类号］ Ｒ473． 71 ［文献标志码］ A ［文章编号］ 2095-140X( 2022) 07-0058-05 ［DOI］ 10． 3969 /j． issn． 2095-140X． 2022． 07． 013
Effects of Mammary Duct Exploration on Lactation Symptoms and Inflammatory Mediators in Patients with Milk Stasis LONG An-li，LIU Xun-jiao，ZHOU Guo-dong，WANG Xin-chou ( Department of Breast Diseases，Guilin Maternal and Child Health Hospital，Guilin，Guangxi Zhuang Autonomous Ｒegion 541001，China) ［Abstract］ Objective To investigate the effect of mammary duct exploration on lactation symptoms and inflammatory mediators in patients with milk stasis． Methods A total of 300 cases of milk stasis treated in our hospital from August 2020 to August 2021 were selected and divided into observation group and control group，with 150 cases in each group according to different treatment methods． The control group received traditional physical therapy，and the observation group received breast duct exploration． The therapeutic effect，rehabilitation-related indicators ( initiation time of lactation，disappearance time of breast induration，milk excretion，breastfeeding status) ，patient satisfaction，incidence of adverse events，recurrence rate，lactation symptom score and inflammatory mediators［serum interleukin-6 ( IL-6) ，interleukin-1α ( IL-1α) ，C-reactive protein ( CＲP) level］were calculated in the two groups． Ｒesults The total effective rate and patient satisfaction of the observation group were higher than those of the control group，the initiation time of lactation and the disappearance time of breast lump were shorter than those of the control group; the milk excretion was more than that of the control group，and the breastfeeding situation was better than that of the control group ( P ＜ 0. 05，P ＜ 0. 01) ． After treatment，the scores of milk stasis，milk quality，milk production，breast filling degree and breast pain in the two groups were higher than those before treatment，which were higher in the observation group than in the control group ( P ＜ 0. 05，P ＜ 0. 01) ． After treatment，the levels of serum IL-1α，IL-6 and CＲP in the two groups were lower than those before treatment，which were lower in the observation group than in the control group ( P ＜ 0. 05，P ＜ 0. 01) ． There was no significant difference in the incidence of adverse events and recurrence rate between the two groups ( P ＞ 0. 05) ． Conclusion Mammary duct exploration is effective in the treatment of milk stasis，which is helpful to relieve lactation symptoms，improve breastfeeding rate and patient satisfaction，and down-regulate inflammatory mediators，with certain safety
乳腺导管探查术对乳汁淤积患者泌乳症状、炎性介质的影响 .pdf
